Our mission is to make disordered proteins druggable.
We are a UK-based not-for-profit Focused Research Organisation (FRO) committed to improving patient outcomes by turning disordered proteins into viable drug targets.
Many incurable diseases (e.g., cancer, neurodegeneration) involve biomolecules called ‘disordered proteins’. Considered ‘undruggable’ by the mainstream pharmaceutical industry, disordered proteins continuously change their three-dimensional shapes and lack long-lived sites with which drug-molecules can interact.
Our mission is to make disordered proteins druggable. We are screening millions of disordered protein/drug-molecule pairs to learn the rules of drugging disordered proteins.
Building on our expertise and working with academic and industrial partners, we are leveraging cutting-edge biology, engineering, and AI to deliver new drugs and tools. We are building comprehensive datasets of disordered protein-drug interactions to create public assets to fuel AI models and accelerate the discovery process. To accomplish this in a manner for maximum societal benefit, we have established a Focused Research Organisation (FRO), a fully-independent not-for-profit entity dedicated to this goal.